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Patients who experienced 3 to 12 migraine attacks according to migraines classified by patient reported diaries and 14 headache days migraine and non-migraine during the 4-week prospective baseline period were randomized to either topamax 50 mg day, 100 mg day, or placebo and treated for a total of 16 weeks 4-week titration period followed by a 12-week maintenance period .

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